Abstract

Improved measurements of biomarkers, drugs, and metabolites in live cells and organisms would allow for improvements in disease detection, drug development, and biomedical research. Quantum well-modified carbon nanotubes (QWNTs) have exciting optical properties for applications as sensors for use in live cells and in vivo, including the potential to increase quantum yield over pristine SWCNTs, and to improve control over photoluminescence modulation in response to the local environment. To develop QWNTs into sensors, we devised new methods to encapsulate them for biocompatibility, as well as new instrumentation for measurements. We also investigated mechanisms of QWNT photoluminescence environmental responsivity, including the dependence of electrostatic charge on spectral red-shifting. We found that this mechanism can amplify measurements of biomarkers, enhancing the development of sensors.

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