Abstract
Rapid, minimally-invasive in situ detection of analytes in vivo remains a goal to study inflammatory signaling molecules and pharmacology of therapeutics. Towards this end, we are using the near-infrared photoluminescent properties of single-walled carbon nanotubes (SWCNT) to design sensors for use in live mice. The photostable, environmental-responsive, tissue-transparent emission of SWCNT is ideal for this application. Therefore, we are working toward in vivo analyte monitoring through a simple injection of hydrogel-encapsulated SWCNT sensors to localize signal to specific sites in the body. We are incorporating machine learning-based approaches coupled with molecular recognition to develop multiplexed SWCNT sensors for several inflammatory signaling proteins (cytokines) as well as chemotherapeutic agents. We are performing high-throughput near-infrared plate reader-based measurements to screen sensor responses prior to in vivo evaluation and testing with patient samples. We anticipate in vivo evaluation to lead to real-time understanding of inflammatory disease biology and drug pharmacology in the short-term, while long-term applications may include minimally-invasive and rapid clinical diagnostic development.
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