Abstract
Oliver Wendell Holmes, the American physician and humorist offered the following quote: “The great thing in the world is not so much where we stand, as in what direction we are moving.” This is certainly true of the field of extracellular matrix biology, especially in the context of heart disease. Despite the pioneering work of Weber, Borg, Caulfield, and others, the role of the cardiac matrix was somewhat ignored as a player in the pathogenesis of heart failure until the past decade. This view is now changing, and in 2008, Doris Taylor (from the University of Minnesota) used a perfused rat heart to create decellularized cardiac matrix constructs, and she has demonstrated the critical role of the matrix in organizing reintroduced cardiac myocytes to produce a bioartificial functioning cardiac pump de novo [1].
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