Abstract
Building a more complete understanding of venous diseases requires a coordinated effort between basic scientists and clinicians. Venous diseases, as a subset of cardiovascular diseases, combine organic chemistry, cell and tissue biology, and flow physics events that interact simultaneously in a complex and intimate relationship in both healthy and diseased states. Dissecting the importance of each of these participants in a given situation is critical for understanding the mechanisms of disease. However, it is crucial that we carefully consider the biophysics interplay and focus our efforts on understanding the complete clinical scenario, thus ultimately promoting the clinical translation ability of our results. Phenotypic and functional transformation in smooth muscle cells derived from varicose veinsJournal of Vascular Surgery: Venous and Lymphatic DisordersVol. 5Issue 5PreviewVaricose veins (VVs) are a common disorder of venous dilation and tortuosity, but the underlying mechanism is unclear. The functional integrity and phenotypic differences of VVs are also unclear. This study tested the hypothesis that phenotypic and functional differences exist between smooth muscle cells (SMCs) derived from VVs and normal veins. Full-Text PDF
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