Abstract
Apoptosis or program cell death has been previously reported to occur during cardioplegic arrest and cardiopulmonary bypass (CPB), suggesting that apoptosis may, at least in part, contribute to myocardial stunning. Vähäsilta and colleagues [1] confirmed these previous findings in their in-vivo pig model and further tested the hypothesis that differences from retrograde and antegrade cardioplegia might translate into differences in appearance of apoptosis. In this interesting and important study, the authors found that retrograde cardioplegia induced higher amount of apoptosis cardiomyocyte death than antegrade cardioplegia.
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