Abstract
Malignant pleural mesothelioma (MPM) is a rare, asbestos-induced malignancy, which carries a dismal prognosis despite multimodality therapy. The histologic subtypes of MPM—epithelial, biphasic, and sarcomatoid—suggest that epithelial-to-mesenchymal transition (EMT) may play a central role, and provide context for the aggressiveness nature of these tumors. EMT is a complex molecular and cellular program by which epithelial cells shed their differentiated characteristics and acquire mesenchymal features, including lack of polarity, increased motility and invasiveness, and resistance to apoptosis.
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