(Invited) Closed-Loop Electrostimulation Enabled by Nanogenerator Technology

Abstract

Electrostimulation (ES) has long been utilized as a versatile therapeutic strategy for treating human diseases. The nanogenerator technology stands at a unique position for connecting biological ES to body motions by converting biomechanical energy to electric pulses. This process forms a closed-loop ES in both energy flow and function feedback. This talk will first elaborate how the closed-loop ES operates as a close analogue to how the body controls its own functions. The most recent progresses of flexible and complex piezoelectric material innovations in our group will be viewed for implantable nanogenerator development, including 3D printing techniques and degradable piezoelectric biomaterials. These materials exhibited tissue-matching mechanical property as well as excellent electromechanical coupling properties, ideal for in situ electrostimulation generation. In our recent research, we also successfully implemented the closed-loop electrostimulation concept for skin wound healing, hair growth, bone healing and vagus nerve stimulation for obesity control with superb performance. An electrical stimulation bandage was developed that could accelerate skin wounds recovery to within 3 days as compared to 12 days of usual contraction-based healing processes in rodents. Via a similar design, the electrical pulses were applied to stimulate hair growth. In another work, an implanted vagus nerve stimulation system was developed in responsive to the peristalsis of stomach. The electric signals generated by this device stimulates the vagal afferent fibers to reduce food intake and achieve weight control. With the advanced electromechanical material and device design and engineering, the closed-loop electostimulation concept will quickly grow into a very impactful application direction of nanogenerator technology for human wellbeing.