Abstract
A challenge of particular interest in the fields of biosensing and bioimaging is the acquisition of real-time readouts of localized bioanalyte concentration through biomaterials and live tissue in a minimally-invasive fashion. The intrinsic fluorescence of single-walled carbon nanotubes (SWCNTs), which exhibits exceptional photostability, near-infrared (NIR) material-penetrating emission, and microenvironmental sensitivity, makes them ideal candidates for a variety of biomedical imaging and sensing applications. By functionalizing SWCNTs with appropriate biopolymers, we can simultaneously impart biocompatibility as well as sensitivity and selectivity for certain biomolecules of interest. Using novel spectroscopy and microscopy approaches, this talk features our recent advances in the development of such engineered nanomaterials as NIR fluorescence biosensors. In particular, we have created an electrospun microfibrous biomaterial with encapsulated SWCNTs. The novel optical material responds in real-time to specific biomarkers released from cells.
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