Abstract
Photodynamic therapy (PDT), an emerging non-invasive tumor treatment, requires suitable photosensitizer (PS) molecules that generate reactive oxygen species (ROSs) efficiently under long wavelength of light with deep tissue penetration, ideally activated in the diseased tissue. C60 is known as an excellent acceptor molecule in both electron- and energy-transfer reactions and exhibits biocompatibility and efficient ROS generation, rendering it a promising candidate as a PS for PDT.In this study, we developed a C60-based dual-functional molecular probe containing a water-soluble C60-peptide and a donor fluorophore connected with a ligand peptide specific for matrix metalloproteinases (MMP) (Figure 1). We expect that such a molecular probe can be used in both diagnostic imaging and concurrent treatment. The probe revealed increased fluorescence signal and 1O2 generation in the presence of MMP2/9 enzymes that are known to be overexpressed in tumor cells. Furthermore, in vitro cellular tests demonstrated the probe's abilities in imaging MMP activity and photocytotoxicity on MMP-expressing tumor cells. Figure 1
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