Abstract
Synthesis of N-substituted derivatives of 4-alkoxy-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones ( 10– 14, 18– 21) is described. In the “writhing syndrome” test all compounds studied exhibited potent analgesic activity which was superior than that of acetylsalicylic acid. In the “hot plate” test imides 10, 12, 13, 18– 20 acted also stronger than aspirin. Furthermore all compounds tested significantly suppressed the spontaneous locomotor activity of mice and prolonged barbiturate sleep of these animals.
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