Investigations on the relationship between molecular structure and chromatogenic parameters: I. Two homologous series of pyridine derivatives suitable as reference compounds in liquid-liquid partition chromatography

Abstract

RM values of several 4-pyridyl alkyl ketones and 4-pyridyl alkyl alcohols determined for a number of aqueous and non-aqueous liquid-liquid partition chromatographic systems, were found to be linearly dependent on the number of carbon atoms in the alkyl chain. The RM values of the ketones or alcohols varied in the range of optimal accuracy of chromatographic data; the compounds are thus proposed as reference solutes for liquid-liquid partition chromatography, using a method analogous to that of the Kovats' indices employed in gas-liquid partition chromatography.