Investigations on the micellization behavior and thermodynamic characteristics of synthesized surface active ionic liquids [C14mim] [Br] and [C15mim] [Br] in the presence of oral antidiabetic drug metformin hydrochloride

Abstract

The present examination focuses on understanding the micellization behavior of surface active ionic liquids 1-tetradecyl-3-methylimidazolium bromide [C14mim] [Br] and 1-pentadecyl-3-methylimidazolium bromide [C15mim] [Br] in presence of antidiabetic drug metformin hydrochloride by employing conductivity measurements and IR spectroscopy. The CMC value and value of counter ion dissociation (α) has been calculated by utilizing conductivity measurements. The dependency of CMC value evaluated from conductivity measurements in aqueous medium and presence of different weight percentage (0.03, 0.05 & 0.07) of drug metformin hydrochloride in aqueous medium and at different temperatures (298.15, 308.15 & 318.15) has been employed to calculate various thermodynamic parameters such as standard free energy of micellization (ΔGm0), standard enthalpy of micellization (ΔHm0), and standard entropy of micellization (ΔSm0). There is a significant increase in CMC value with the rise in temperature signifying delay in micellization process with increasing temperature. Further, the structural alterations prevailing in the selected system (ionic liquid-drug) has been determined by FT-IR Spectroscopy.