Abstract
The crystal structures of two pseudopolymorphic modifications of the glucocorticoid hydrocortisone were determined, in addition to the known structures of the 2-propanol (1), methanol (2) and pyridine (3) solvate reported recently. The chloroform solvate (4) and the N,N′-dimethylformamide solvate (5) crystallize in the monoclinic space group P21, with a = 12.5947 (8) A, b = 12.4413 (5) A, c = 14.9884 (11) A, β =90.571 (9)°, V = 2348.5(2) A3 for (4) and a = 13.4186 (10) A, b = 6.0878 (3) A, c = 14.6595 (11) A, β = 104.711 (10)°, V = 1158.27(14) A3 for 5. The crystal structures of 1, 3, and 5 are isotypic and are very similar to that of the thermodynamically metastable solvent free modification III of hydrocortisone. The removal of solvents from the pseudopolymorphic forms at elevated temperatures results in the formation of the thermodynamically most stable form I or the metastable form II of hydrocortisone. For the methanol solvate, the desolvation reaction indicates the formation of a new modification of...
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