Investigations on 3D-structure, properties and antibacterial activity of two new curcumin derivatives

Abstract

Two chemically and biologically important curcumin derivatives, namely (3E, 5E)-3, 5- bis (3-ethoxy-4-methoxybenzylidene)-1-methylpiperidine-4-one and (3E, 5E) -3, 5-bis (2, 4 -dimethoxybenzylidine) -1-methylpiperidine - 4 - one was synthesised from the mixture of 3-ethoxy-4-methoxybenzaldehyde and 1-methyl piperidone (EMPM) and 2,4-dimethoxybenzaldehyde with 1-methyl piperidone (MBMP). The resultant compounds were chemically characterised using X-ray techniques. Both the compounds were crystallised in a triclinic crystal system with space group Pī and their 3D structures were stabilised by the weak CH···O, CH···π, and π… π intermolecular interactions. The title materials were also analysed for their optical properties via NMR, UV–vis, FTIR, and PL spectra. TG and DTA thermograms of the compounds were investigated to derive melting points, thermal stability, and other associated thermal processes. Information about short contacts such as CH…π, and π…π molecular interactions was studied using Hirshfeld surfaces analysis. In vitro screening of the compounds has been performed for their antibacterial activity, which discloses their highly promising antibacterial properties against the tested microorganisms.