Abstract
Monodispersed magnetite nanoparticles were obtained by investigating the different synthesis parameters of the solvothermal method. The morphology and chemical structure of the Fe3O4 nanoparticles were characterized by Fourier transform infrared spectrometer (FT-IR), X-ray diffraction (XRD), Scanning electron microscope (SEM), Transmission electron microscope (TEM), Dynamic Light Scattering (DLS) and Vibrating sample magnetometer (VSM). Results indicated that without the addition of water, it forms the minor phase of iron instead of magnetite. Furthermore, the size of nanoparticles is tunable in the range of 117.7 to 217.6 nm by changing the amounts of water, PSSMA and NaOH. The amount of PSSMA restricts the growth of the nanoparticles and narrow the size distribution and a hydrophilic surface was obtained. Synthesized magnetite nanoparticles were successfully conjugated with carbon dots. The resulting nanoparticles exhibited good fluorescence characteristics. Cytotoxicity tests confirmed that nanoparticles are non-toxic. Both magnetite and C-dots/Fe3O4 nanoparticles are good potential candidates for biomedical applications specifically for bioimaging and biosensing in the future.
Highlights
For the past few years, magnetic nanoparticles have drawn a great deal of attention
Industrial applications of magnetic nanoparticles cover a large spectrum of magnetic recording,1 environmental remediation,2 ferrofluid technology,3 biomedical applications for example magnetic resonance imaging (MRI)4 and therapeutic agents in cancer treatment
Different parameters were investigated for the synthesis of magnetite nanoparticles
Summary
For the past few years, magnetic nanoparticles have drawn a great deal of attention. Industrial applications of magnetic nanoparticles cover a large spectrum of magnetic recording, environmental remediation, ferrofluid technology, biomedical applications for example magnetic resonance imaging (MRI) and therapeutic agents in cancer treatment. Each potential application of the magnetic nanoparticles requires different properties. The major factors, which determine toxicity and the biocompatibility of these materials, are the nature of the magnetically responsive components, such as iron, nickel, and cobalt, and the final size of the particles, their core and the coatings Iron oxide nanoparticles, such as magnetite (Fe3O4), maghemite (γ-Fe2O3), and hematite (α-Fe2O3) are by far the most commonly employed in different fields in particular in biomedical applications.. The solvothermal process is one of the successful methods for growing crystals in which the grains formed have a better crystallinity than those obtained with other methods, and it has been used to obtain Fe3O4 fine particles with highly uniform sizes, hydrophilic surface and aqueous dispersibility.25 These characteristics can be altered by changing certain experimental parameters, including reaction temperature, reaction time, solvent type, surfactant type, and reductant type. Best results from the parameters will be conjugated with carbon dots for potential biomedical applications
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