Abstract
Background: FS-1 is a complex of iodine and synthesized polysaccharides and it is very effective against a number of microbe and virus strains. The aim of the study was to evaluate possible genotoxic properties of FS-1. Methods: The compound was studied in rat and mouse bone marrow micronucleus (MN) assay and the comet assay in murine peripheral blood leukocytes, hepatocytes, and kidney cells. Two treatment protocols were applied, namely acute and subacute ones. In the first protocol, the compound was administered orally once and in subacute treatment two times, 24 h apart. The animals were sacrificed 24 h after the last treatment, and appropriate cells were used to assess DNA damage and MN induction. Results: In none of the tests (MN and comet assays) significant increase compared with respective negative controls was observed. Conclusion: The fact that the compound neither induces DNA damage in various organs of mice nor is effective in the induction of MN in bone marrow cells of rats and mice is important for future genotoxicity studies of FS-1, which can be used in clinical medicine after additional testing of safety for humans.
Highlights
A very effective drug against a number of strains of microbes and viruses has recently been invented and patented (KZ Patent No 15116) in Kazakhstan
The compound was studied in rat and mouse bone marrow micronucleus (MN) assay and the comet assay in murine peripheral blood leukocytes, hepatocytes, and kidney cells
4State Medical University, Yerevan, Armenia, Conclusion: The fact that the compound neither induces DNA damage in various organs of mice nor is effective in the 5Yerevan State University, Yerevan, Armenia, induction of MN in bone marrow cells of rats and mice is important for future genotoxicity studies of FS-1, which can 6AUA, Faculty of Clinical Medicine, be used in clinical medicine after additional testing of safety for humans
Summary
A very effective drug against a number of strains of microbes and viruses has recently been invented and patented (KZ Patent No 15116) in Kazakhstan. FS-1 is a complex of iodine with synthesized polysacneurological pathology, and it dramatically improves the quality of life Received: 21.04.2011 reflecting on enhanced treatment adherence. ILαD appears to be safe such as bacteria, viruses, fungi, and protozoa [1]. FS-1 is a compound structurally very similar to ILαD. FS-1 is very potent in veterinary medicine against many infectious factors is planned to be applied in a small clinical trial in HIV-infected patients. Because of its low toxicity in rodents [i.e., 25 Before the trial, the safety of the compound should be proved
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
