Abstract
The main effective components of Rhubarb are anthraquinones (AQs), most of which are glycoside and others are free. The concentrations of AQs derivatives (rhein, aloe-emodin, emodin and chrysophanol) in plasma and homogenate were assayed with a high performance liquid chromatography (HPLC) method. The pharmacokinetic parameter and distributions of rhubarb AQs in rabbits or rats were obtained after given different formulas respectively. The elimination of AQs was fit to a two-compartment model in rats and rabbits. There were no significant differences in the main pharmacokinetic parameters between with rhein and AQs in rats. AQs were distributed in kidney, liver, blood, heart progressively. The AQs were mainly existed as rhein in vivo and excreted by kidney. To the formulas containing rhubarb, rhein could be used as a probe for pharmacokinetic study of Rhubarb AQs in vivo.
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