Abstract
Objective:We conducted a case-control study with 322 cases and 322 controls to assess the role of the two common SNPs in the promoter of IL-18 gene.Methods:Polymerase chain reaction restriction fragment length of polymorphism (PCR-RFLP) was taken to genotype -607A/C and -137C/G in the promoter of the IL-18 gene.Results:By comparing cases and control subjects, we found that IS cases were more likely to have higher BMI, higher proportion of hypertension, and have higher proportion of smokers and drinkers. We found that IL-18 -607CC genotype (OR=1.70, 95% CI=1.03-2.81) and C allele (OR=1.26, 95% CI=1.01-1.58) were significantly more frequent in IS patients when compared with AA genotype. We did not find significant association between IL-18 -607A/C gene polymorphism and BMI, hypertension, smoking and drinking on the risk of IS.Conclusion:Our study suggests that polymorphisms in IL-18 -607A/C can influence the development of IS, and this gene polymorphism is associated with risk of IS in a Chinese population.
Highlights
Stroke is a leading cause of death, and this disease causes long-term disability in the world
Previous studies indicated that several certain polymorphisms in inflammatory genes can influence the risk of ischemic stroke (IS), such as intereleukin-6 (IL-6), transforming growth factor (TGF-B1), interleukin-1 receptor antagonist (IL-1Ra), IL-1a and IL-1B and tumor necrosis factors.[4,5,6,7,8]
The current study showed that IL-18 -607A/C polymorphisms can influence the risk of IS
Summary
Stroke is a leading cause of death, and this disease causes long-term disability in the world. IL-18 is a member of the IL-1 superfamily, and this gene is a pleiotropic pro-inflammatory cytokine and has a role in the inflammatory cascade.[9] Two previous studies have reported that higher level of IL-18 is associated with increased risk of IS.[10,11]. Previous studies have shown that C allele of IL-18-607A/C and G allele of IL-18137C/G could affect the IL-18 higher transcription and its protein production.[14,15] Previous studies have shown that IL-18 gene polymorphisms are correlated with risk of cardiovascular disease.[16,17] few studies have reported the association between IL-18 polymorphisms and risk of IS. In order to assess the role of the two common SNPs of the promoter of IL-18 gene in the risk of IS, we conducted a case-control study with 322 cases and 322 controls in a Chinese population
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
