Investigation on Mechanical, Biocorrosion, and Biocompatibility Behavior of HAp-Assisted Sr-Based Mg Composites

Abstract

Numerous biodegradable Mg-based biomaterials have been developed in recent years because of their outstanding biocompatibility, biodegradation, and mechanical properties. The Mg-based composite is an appropriate candidate for orthopedic implants, such as supporting the fractured bone due to its superb biocompatibility and biodegradation properties. In the present work, a Mg-based biomaterial is developed by incorporating low wt % of alloying elements such as Zn, Ca, Mn, and Sr and ceramic powders such as HAp to improve the biocompatibility and biodegradebility and strengthen the mechanical properties. In this study, the Mg-4Zn-3Ca-1HAp-0.5Mn and Mg-4Zn-2.9Ca-1HAp-0.5Mn-0.1Sr composites are prepared, and the mechanical, microstructure, and in vitro degradation behavior of these composites are studied. The Mg-4Zn-2.9Ca-1HAp-0.5Mn-0.1Sr composite has good mechanical properties and a low uniform in vitro degradation rate (0.587 mm/year). From the dynamic mechanical analysis, it is found that the composites have better damping characteristics than the pure Mg. The composites are chosen for further evaluation. All the composites show no cytotoxicity to MG63 cells. The composite having Sr with PVA/ZrO2 coating showed the highest cell viability. On the basis of the above observation, the viability of the Mg-4Zn-3Ca-1HAp-0.5Mn and Mg-4Zn-2.9Ca-1HAp-0.5Mn-0.1Sr composites is discussed systematically for the use as an orthopedic implant. This investigation delivers a new idea for the evolution of a high-performance Sr-based Mg composite having excellent mechanical and corrosion properties while successfully reducing the cytotoxicity effect.