Abstract
Nowadays, during the polarization of neutrophils, the function of the mechanical force transducer PIEZO1 is still unclear. Our research shows that the PIEZO1 gene knockout in tumor-associated neutrophils (TANs) can suppress the polarization of TANs towards the N2 phenotype induced by TGF-β; Activating PIEZO1 by Yoda1 promotes polarization. We discover that cancer cell proliferation is enhanced by coculturing colorectal cancer cells with N2 TANs. On the contrary, when PIEZO1 is knocked out, the cancer development alleviates due to its prevention of TANs polarizing towards N2. Our research hints that mechanical force transducer PIEZO1 might be a new target spot during the treatment of colorectal cancer.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
