Abstract
Abstract Four mononuclear metal chelated complexes, [Co(L)] (1), [Ni(L)] (2), [Cu(L)] (3) and [Zn(L)] (4), were designed and synthesized from a novel quadridentate salen-type Schiff base ligand (H2L) derived from 2-hydroxy napthaldehyde and 4-fluoro-1,2-phenylenediamine. The chemical structures of synthesized compounds were fully characterized by various techniques. Spectral and analytical investigations clearly suggested that a square planar geometry around metal centre. The thermal analysis (TGA) of these complexes indicated greater thermal stability and various steps involved in thermal decomposition of metal complexes. The binding ability between the metal complexes and CT-DNA was investigated by UV-Vis, fluorescence spectroscopy and viscometric experiments which revealed an intercalation binding mode of binding. The cleavage property of metal complexes against pBR322 DNA has been explored. The antioxidant activity of M(II) complexes against active free radicals was determined by DPPH free radical scavenging experiment. Furthermore all compounds were screened against antimicrobial activity.
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