Abstract
Psoriasis affects more than 125 million people worldwide, and the diagnosis and treatment efficacy evaluation of the disease mainly rely on clinical assessments that could be subjective. Our previous study showed that the skin erythema level could be quantified using diffuse reflectance spectroscopy (DRS), and the hemoglobin concentration of most psoriatic lesion was higher than that of its adjacent uninvolved skin. While the compromised epidermal barrier function has been taken as the major cause of clinical manifestation of skin dryness and inflammation of psoriasis, very few methods can be used to effectively evaluate this function. In this study, we investigate the near infrared spectroscopic features of psoriatic (n = 21) and normal (n = 21) skin that could link to the epidermal barrier function. From the DRS measurements, it was found that the water bonding status and light scattering properties of psoriasis are significantly different from those of uninvolved or normal skin. The connection between these parameters to the epidermal barrier function and morphology will be discussed. Our results suggest that objective evaluation of epidermal barrier function of psoriasis could be achieved using a simple DRS system.
Highlights
Psoriasis affects more than 125 million people worldwide, and the diagnosis and treatment efficacy evaluation of the disease mainly rely on clinical assessments that could be subjective
It has been identified through various studies that the defective barrier function of psoriatic skin can be noninvasively monitored with transepidermal water loss (TEWL) m easurements[5,6]
Researchers carried out studies to measure the TEWL and skin impedance of psoriasis, and it was found that the epidermal hydration and barrier function were both decreased compared with normal skin[7,8]
Summary
Psoriasis affects more than 125 million people worldwide, and the diagnosis and treatment efficacy evaluation of the disease mainly rely on clinical assessments that could be subjective. From the DRS measurements, it was found that the water bonding status and light scattering properties of psoriasis are significantly different from those of uninvolved or normal skin. The connection between these parameters to the epidermal barrier function and morphology will be discussed. By using laser doppler imaging, Hendriks et al found alteration in microcirculation of psoriatic lesions was correlated with the skin inflammation s tatus[4] It has been identified through various studies that the defective barrier function of psoriatic skin can be noninvasively monitored with transepidermal water loss (TEWL) m easurements[5,6]. We observed increased hemoglobin concentration in the dermis and increased mean size of tissue scatterers induced by epidermal hyperplasia on Scientific Reports | (2021) 11:8901
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