Investigation of Volumetric and Optical Properties of Anti-Emetic Metoclopramide Hydrochloride Drug in Aqueous-Dimethylsulfoxide (DMSO) Solutions At 303.15 K

Santosh Deosarkar,Rajendrakumar Sawale,Tukaram Kalyankar

doi:10.7324/japs.2015.50503

Abstract

Article history: Received on: 27/03/2015 Revised on: 12/04/2015 Accepted on: 03/05/2015 Available online: 27/05/2015 In view of pharmaceutical applications, the density (ρ) and refractive index (nD) of antiemetic metoclopramide hydrochloride monohydrate (MHM) drug in aqueous, aqueous-DMSO and DMSO solutions were measured at 303.15 K in the wide range of concentration of drug. Apparent molar volumes (φv) were calculated from density data and fitted to the Masson relation to determine partial molar volume (φ °v) of drug. Overall, strong drugsolvent interactions with significant structural changes in pure and mixed solvents have been confirmed.

Highlights

Nowadays, major efforts are devoted to study physicochemical properties of biomolecules in mixed solvent because of their binding trends with the medium
In view of pharmaceutical applications, the density (ρ) and refractive index of antiemetic metoclopramide hydrochloride monohydrate (MHM) drug in aqueous, aqueous-DMSO and DMSO solutions were measured at 303.15 K in the wide range of concentration of drug
Experimental density ( ) and refractive index data of binary DMSO-water mixtures is reported in Table 1 and 2

Summary

Introduction

Major efforts are devoted to study physicochemical properties of biomolecules in mixed solvent because of their binding trends with the medium. Volumetric properties such as density, apparent and partial molar volumes of drug solutions are of fundamental importance. Solution properties of metoclopramide hydrochloride in pure solvents such as water and DMSO and in mixed DMSO-water are lacking despite their physiological importance. An effort has been made here to study the physicochemical properties such as density, refractive index and apparent and partial molar volumes of metoclopramide hydrochloride in water, DMSO and 30, 50 and 70% v/v DMSO-water mixtures.

Results

Conclusion