Abstract
BackgroundObstructive sleep apnea (OSA) is a disease seriously threatening individual health, which results in serious complications such as hypertension and stroke. These complications are associated with oxidative stress triggered by intermittent hypoxia in OSA. Sestrin2 is a crucial factor involved in oxidative stress. The goal of this study was to investigate if a relationship exists between OSA and Sestrin2.MethodsWe prospectively enrolled 71 subjects, and 16 patients of them with severe OSA completed 4 weeks of nasal continuous positive airway pressure (nCPAP) therapy. We measured and compared the concentration of Sestrin2 in the urine of all subjects, as well as the changes between before and after nCPAP treatment. Additionally, the correlation between Sestrin2 and sleep parameters was analyzed, and the multiple linear regression analysis with stepwise selection was performed to explore the relationship between Sestrin2 and various factors.ResultsA total of 71 subjects were enrolled and divided into two groups: OSA group (n = 41), control group (n = 30). The level of urinary Sestrin2 in OSA patients was significantly higher than that of the control group, and increased with the severity of OSA, while it reduced after nCPAP treatment. Additionally, Sestrin2 was positively correlated with apnea/hypopnea index (AHI), oxygen desaturation index, oxygen saturation < 90% percentage of recording time spent (PRTS) and high-density lipoprotein (HDL), while negatively correlated with the lowest oxygen saturation. Importantly, Sestrin2 was independently associated with AHI, oxygen saturation < 90% PRTS and HDL.ConclusionsUrinary Sestrin2 is involved in OSA, and is a paramount marker of OSA severity.
Highlights
Obstructive sleep apnea (OSA) is a shared sleep-related disorder
The estimated prevalence of OSA is 0.7–3.3% [1,2,3]. It is characterized by periodic recurrent episodes of upper airway obstruction during sleep, resulting in apnea [4], and the occurrence of OSA is capable of disrupting sleep integrity, impairing ventilation, and resulting in intermittent hypoxia [5], which seriously lead to coronary artery disease, high blood pressure, cerebrovascular accident, stroke, etc
This study was the first report on investigation of Sestrin2 in OSA, and the results showed that the Sestrin2 level elevated in OSA and decreased after nasal continuous positive airway pressure (nCPAP) treatment
Summary
The estimated prevalence of OSA is 0.7–3.3% [1,2,3] It is characterized by periodic recurrent episodes of upper airway obstruction during sleep, resulting in apnea [4], and the occurrence of OSA is capable of disrupting sleep integrity, impairing ventilation, and resulting in intermittent hypoxia [5], which seriously lead to coronary artery disease, high blood pressure, cerebrovascular accident, stroke, etc. Obstructive sleep apnea (OSA) is a disease seriously threatening individual health, which results in serious complications such as hypertension and stroke. These complications are associated with oxidative stress triggered by intermittent hypoxia in OSA. Conclusions Urinary Sestrin is involved in OSA, and is a paramount marker of OSA severity
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