Abstract
Investigation of p53 immunoreactivity in formalin-fixed paraffin-embedded tissues of normal renal tissue and renal cell carcinoma with respect to histopathologic subtype and nuclear grade of RCC. 42 tissue sections of RCC and 5 samples of normal renal tissue were stained for p53 expression using immunohistochemical assay. The results were analyzed in relation to nuclear grade and histopathologic subtype. In total, p53 expression was found to be 4 to 5 times higher (30.8%) in other types of RCC than in the clear-cell type of RCC (6.9%). Further, there was no statistically significant difference in p53 overexpression among the histopathologic subtypes (P>0.05, P=0.063). No association was found between the expression of p53 and nuclear grade (P>0.05, P=0.17). Interestingly, our study also showed weak cytoplasmic positivity in renal tubular epithelium. Our findings suggest that p53 might play an important role in tumour development or progression and it might be used as a new predictor and therapeutic target for RCC.
Highlights
Renal cell carcinoma (RCC) accounts for approximately 85% of all kidney cancers
While some investigators have found no association[11], a strong relationship has been demonstrated by others and it is regarded as a potential marker in determining the prognosis of patients with RCC
We investigated p53 immunoreactivity in formalin-fixed paraffin-embedded tissues of normal renal tissue and renal cell carcinoma
Summary
There are at least five subtypes of RCC currently recognized and the most common form is clear cell cancer, which accounts for roughly 70% to 80% of cases. This tumour is characterized by exceptionally high resistance to radiation and chemotherapy[1], which can be explained in part by naturally high levels of expression of multidrug transporters and elevated activity of the glutathione system in RCC progenitors, kidney tubular epithelial cells. Investigation of p53 immunoreactivity in formalin-fixed paraffin-embedded tissues of normal renal tissue and renal cell carcinoma with respect to histopathologic subtype and nuclear grade of RCC. Our findings suggest that p53 might play an important role in tumour development or progression and it might be used as a new predictor and therapeutic target for RCC
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