Abstract
INVESTIGATION OF THYROID FUNCTION AND AUTOANTIBODIES IN PATIENTS WITH CHRONIC HEPATITIS B AND C I. Orsagova, L. Roznovsky, I. Lochman 1 Dept. of Infectious Diseases, University Hospital, Ostrava, Czech Republic. 1Regional Institute of Hygiene, Ostrava, Czech Republic. Background: Thyroid function and some types of autoantibodies were investigated in 94 patients with chronic hepatitis B and C in dependence on antiviral therapy. Material and methods: 24 patients with hepatitis B were treated by interferon-~x and 70 patients with chronic hepatitis C were treated by intefferon~ alone or combination with ribavirin. Thirteen patients with hepatitis C suffered also from congenital coagulopathies (10 hemophilia A, 3 von Willebrand disease). Before, during and after the treatment we investigated following markers: thyroid function (T3, T4, TSH), two types of autoantibodies against thyroid gland, anti-LKM antibodies, antismooth muscle antibodies, four types of antimitochondrial antibodieS, 3 types of nucleic acid antibodies and ANCA antibodies. Results: Mostly mild changes in thyroid function were observed in 42 patients. Autoantibodies against thyroid gland appeared in 7 patients. Other pathological markers of auto-immunity were observed the following: nucleic acid antibodies in 22 individuals, anti-smcoth muscle antibodies in 3, antimitucbondrial antibodies in 4, ANCA antibodies in 1 patient. These findings didn't require preliminary interruption of interferon~ therapy. Serious adverse effects were observed in 3 patients. Clinical apparent hypothyreosis grew up in one woman, hyperthyreosis in one man during the therapy. Muscular disturbance with possible autoimmune hepatitis appeared in the third patient. Conclusions: Presence of some changes in thyroid markers and some types of autoantibedies had no clinical significance and didn't affect the intefferon-~ therapy in most patients with chronic hepatitis B and C. COrd103 ]
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