Investigation of Therapeutic Potential of Biosynthesized Silver and Gold Nanoparticles Using Extract of Wrightia tinctoria

Abstract

Background:: In Indian traditional medicine, the seeds and bark of Wrightia tinctoria are utilized as remedies for antidiarrheal and antidysenteric purposes, as well as for other medicinal uses. Aim:: The primary aim of the study was to explore the green synthesis of silver and gold nanoparticles by employing an extract obtained from the Wrightia tinctoria plant and to explore their potential medicinal properties. Objective:: This study involved the characterization of the nanoparticles in terms of their properties and quality, as well as an investigation of their potential anti-bacterial, anticancer, and antiinflammatory properties. Methods: Various characterization techniques, including UV spectroscopy, XRD spectra, FTIR, SEM, particle size and zeta potential analysis, were used in this study for the synthesized nanoparticles. Our study investigated the impact of concentration, pH, and incubation time on nanoparticle synthesis, providing a comprehensive description of the synthesis procedure for both silver and gold nanoparticles. Result:: Experimental findings confirmed that silver and gold nanoparticles derived from Wrightia tinctoria exhibited irregular shape, with an average diameter ranging from approximately 0.08 to 0.34 μm and 0.09 to 0.30 μm, respectively. Appreciably, the biologically synthesized WTAgNPs and WTAuNPs demonstrated promising antibacterial, anticancer, and anti-inflammatory properties without any signs of toxicity. The enhanced biological activity of WTAgNPs and WTAuNPs can be attributed to their distinctive properties at the nanoscale, as both exhibit lower polydispersity and average particle size, contributing to increased reactivity and interactions with biological systems. Conclusion:: The nanoparticles synthesized through the biogenic approach using Wrightia tinctoria extract have immense potential for a wide range of pharmaceutical applications.