Abstract

Abstract Objective G719X is the most frequently seen uncommon mutation of the epidermal growth factor receptor (EGFR) gene, which is a point mutation at exon 18 with three common subtypes, G719A/G719C/G719S. This study explored the clinicopathological characteristics of the G719X mutation and investigated the efficacy of EGFR-tyrosine kinase inhibitor (TKI) treatment and chemotherapy in patients with the G719X mutation; the survival rate after these different treatment modalities were then analyzed in order to provide evidence for clinical treatment. Methods Clinical data of 41 patients with the G719X mutation admitted in the Beijing Chest Hospital, Capital Medical University from September 2014 to July 2018, were collected and the EGFR mutations were detected by amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). The clinicopathological characteristics of the G719X mutation were analyzed, and the relationship among the G719X mutation, the efficacy of different treatment modalities, and the progression-free survival (PFS) was analyzed. Results Of the 41 cases, 24 (58.5%) were G719X single mutations and 17 (41.5%) were compound mutations, including G719X/S768I, G719X/L861Q, G719X/19del, and G719X/c-Met compound mutation. The objective response rate (ORR) of first-line EGFR-TKI therapy was 50% (6/12), the disease control rate (DCR) was 83.3% (10/12), and the median PFS (mPFS) was 9 months. After resistance to EGFR-TKI in the previous treatment, the ORR (71.4%, 5/7) and DCR (100%, 7/7) were still high following EGFR-TKIs, by an mPFS of 8 months. The ORR of chemotherapy was 33.3% (2/6), the DCR was 100% (6/6), and the mPFS was 6 months. Conclusion G719X is an uncommon mutation of the EGFR gene and is sensitive to many EGFR-TKIs. It can be treated with the second- or third-generation EGFR-TKIs after resistance to the first-generation EGFR-TKIs. G719X mutation also showed favorable effect to chemotherapy.

Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.