Investigation of the thyroid function in end-stage renal failure disease in a Baquba teaching hospital/Diyala governorate - Iraq

Abstract

Renal failure is the inability of the kidneys to excrete nitrogenous waste products, resulting in their retention in the bloodstream. Several correlations exist between renal and thyroid functions; however, end-stage renal failure is unlikely to be influenced by thyroid hormone function and is connected to a higher prevalence of hypothyroidism. The purpose of this study is to ascertain how thyroid status and renal function relate to renal failure patients. Serum creatinine and urea levels were tested in 50 healthy persons and 100 patients with renal failure illness. The acquired data showed that, in comparison to the control group, the average levels of creatinine and urea were significantly higher. The sick group recorded (122.98 mg/dL and 6.55 mg/dL) and (28.38 mg/dL and 0.75 mg/dL) in comparison to the control group, which has urea and creatinine values within the virtually normal range, respectively. In contrast, TSH levels showed no significant differences and have values within the normal range of TSH values, with 2.33 mIU/L for the experimental group and 2.0 mIU/L for the control group. In contrast, T4 values of the experimental group showed significantly lower levels than the control group, with 83.42 ng/dL compared to 103.77 ng/dL. T3 values, however, showed no significant changes and remained within the normal range of 1.75 to 1.64 nmol/L. In addition, the results demonstrated significant differences in the mean levels of anti-TPO, anti-Tg, and anti-TSHR antibodies. The anti-Tg showed a significant decrease in mean values, which were 28.89 IU/ml and 79.49 IU/ml compared to the control group ranges of 34.41 and 86.68 IU/mL. Finally, anti-TSHR showed a significant increase in the mean, which was 1.24 IU/L compared to 1.18 IU/L in the control group.