Abstract
The stability and efficacy of iodine-containing caramels were investigated. In the case of a caramel containing potassium iodide, iodine losses during three months of storage at 60 °C did not exceed 7.9 %. Preclinical trials showed that use of this caramel increased the urinary iodine level to a greater extent than did reference iodine-containing tablets. Clinical trials with caramel showed a statistically significant increase in the median urinary iodine level up to 126.1 μg/L in primary school children against an initial level of 97.1 μg/L (p < 0.05).
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