Abstract
Investigation of the role of the p38 MAPK α and δ isoforms in nonresponse to tumour necrosis factor blockade in the synovium of rheumatoid arthritis patients
Highlights
Rheumatoid arthritis is a chronic inflammatory disorder that primarily affects the joints and results in the destruction of cartilage and subchondral bone by the inflamed synovium
peripheral blood mononuclear cells (PBMC) from systemic sclerosis (SSc) patients responded to TNFα with significantly higher production of leukotriene E4 (LTE4) in comparison with healthy controls (P < 0.05 at 1 hour), while there were no significant differences in TNFα-induced production of 15-hydroxyeicosatetraenoic acid (15-HETE) between SSc patients and controls
It was shown that attachment of synovial fibroblasts (SF) that this association was completely dependent on concomitant from rheumatoid arthritis patients to laminin-111 (LM-111) induced carriage of the PSORS1 risk allele
Summary
Rheumatoid arthritis is a chronic inflammatory disorder that primarily affects the joints and results in the destruction of cartilage and subchondral bone by the inflamed synovium. A observed in affected joints of rheumatoid arthritis (RA) patients, as tourniquet was not used during the procedures and the skin portal well as extensive synovial infiltration of inflammatory cells. These conflicting observations suggest that the regulation of IL-7 expression is tightly controlled at the level of tissue specificity To support this hypothesis, we showed that several cytokines have a different effect on IL-7 production in BM StrC, epithelial cells from the liver and gut. TRU-015 is a CD20-directed small modular immunopharmaceutical drug candidate that effectively depletes B lymphocytes in cynomolgus monkeys in a dose-dependent manner, and improves survival in mouse xenograft tumor models [4,5].
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