Investigation of the relationship between vitamin D serum level with pregnancy success rate in a cycle of in vitro fertilization

Abstract

Aims: The importance of vitamin D in women's health is clear, and many studies have been conducted on the role of this vitamin in reproductive physiology. The main purpose of this examination was to define the association between serum vitamin D level and pregnancy success rate in an in vitro fertilization (IVF) cycle on infertile women between the ages of 20-45. Methods: This retrospective cohort study was done between March 2020 and August 2023, including 134 infertile women with insufficient and 152 infertile women with sufficient vitamin D level. This study investigated the effect of sufficient vitamin D serum level on the IVF method's success. The threshold for determining insufficient vitamin D level was 30 ng/mL, measured by ELISA method seven days before embryo transfer. Results: Our results found that gestational sac and fetal heart rate were statistically significant higher than women with sufficient vitamin D level (p<0.05). Also, there was a statistically significant association between case and control groups regarding live births (p<0.05; 13.4% vs. 75.7%). Based on multiple logistic regression and adjusting for confounding variables, there was a significant difference between the groups in terms of pregnancy success rate (p<0.05). Conclusion: It is concluded that sufficient vitamin D levels increase the chance of success in IVF in Turkish infertile women.