Investigation of the reaction of bis(p-aminophenyl) pyrimidines with maleic anhydride in dimethylacetamide by PME spectroscopy 4. Mechanisms of the autocatalysis of the acylation of amines with carboxylic acid anhydrides in amide solvents

Abstract

1. The carboxy group of amido acids that are formed in the acylation of amines with anhydrides is capable of dissociation in amide solvents with the formation of a free proton. The autocatalysis observed in the acylation of amines with anhydrides in amide solvents has specific acidic character. 2. A mechanism for the acylation of amines with carboxylic acid anhydrides in amide solvents is proposed.