Abstract

7‐Deazapurine containing secondary metabolites and hypermodified tRNA bases are produced in a variety of marine and terrestrial organisms. Although these 7‐deazapurines vary in both their structure and biological roles, they share a common precursor, 7‐cyano‐7‐deazaguanine (preQ0), which is derived from GTP through the action of four enzymes. CDG synthase (QueE) catalyzes the penultimate step, which generates the 7‐deazapurine moiety. QueE is a member of the radical S‐adenosyl‐L‐methionine (SAM) superfamily and catalyzes a complex radical‐mediated ring contraction to convert 6‐carboxy‐5,6,7,8‐tetrahydropterin (CPH4) into 7‐carboxydeazaguanine (CDG). This paper will discuss the structure function relationships that are emerging from studies of this fascinating transformation. This work was supported by NIH grant GM72623 to VB.

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