Abstract
Objective: The aim of the study was to investigate the prophylactic effects of acetyl L-carnitine against to uterus induced by cisplatin. Methods: Twenty-four female Wistar albino rats were divided into four groups: group I (control) was administered with saline; group II was administered with acetyl L-carnitine; group III was administered with cisplatin; group IV was pretreated with acetyl L-carnitine before cisplatin intraperitoneal injection. After 72h of cisplatin injection uterine tissue was removed. Histological and immunohistochemical investigations were performed, respectively. Results: We found that the number of TUNEL and caspases positive cells were increased in the endometrial epithelium, subepithelial connective tissue, endometrial glands and stroma in group III compare to the other groups. Furthermore inflammation and edema were observed in uterus of rats in group III. Conclusion: We can concluded that pretreatment of acetyl L-carnitine administration has protective effect on histological alteration of uterus caused by cisplatin.
Highlights
We aimed to investigate the protective effects of acetyl L-carnitine on cisplatin-induced adverse effects in uterus in our study
Histological results We found that the rat uterus showed normal histological structures with hematoxylin and eosin (H&E)
Group III, intraepithelial lymphocytes were rarely observed in the lumen of endometrial glands and subepithelial edema was not observed in the endometrium of uterus in group IV (Figure 1g,h)
Summary
Experimental studies have reported that carnitine treatment decreased the hepatotoxicity, cardiotoxicity, neurotoxicity and intestine toxicity which are cause of cisplatin injection [13,14,15]. We aimed to investigate the protective effects of acetyl L-carnitine on cisplatin-induced adverse effects in uterus in our study. We observed the inflammatory cell infiltration in the endometrial epithelium, intraepithelial area and subepithelial connective tissue in uterus of rats from group III.
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