Investigation of the pathogenesis of glaucoma capsulare with special discussion of alpha 1 Lp and Cp in aqueous humor.

Abstract

The aqueous humor proteins of exfoliation syndrome were studied qualitatively by crossed immunoelectrophoresis and compared with normal controls. Two kinds of macromolecules (alpha 1-lipoprotein and ceruloplasmin) were detected more frequently in exfoliation syndrome than in the normal controls. Alpha 1 Lp was detected in eight of ten patients with exfoliation syndrome, but in none of the eight controls. Cp was detected in seven of ten patients with exfoliation syndrome, but in only one of the eight controls. The presence of these macromolecules in the anterior chamber suggests high permeability of vessels in the exfoliation syndrome. This interpretation is also supported by the fact that neovascularization is sometimes present in the iris of the exfoliation syndrome. In the aqueous humor from a patient with diabetic retinopathy, ten kinds of aqueous humor proteins were identified.