Abstract
The development of technologies for effective targeted drug delivery for oncotherapy requires the elaboration of new methods to analyze the features of micro- and nanoscale distributions of antitumor drugs in cells and tissues. This paper presents a new approach to three-dimensional analysis of intracellular distribution of cytostatics using fluorescence scanning optical-probe nanotomography technology. Correlative analysis of nanostructure and distribution of injected doxorubicin in studied MCF-7 human breast adenocarcinoma cells made it possible to reveal the features of drug penetration and accumulation in cells. The developed technology based on the principles of scanning optical probe nanotomography is applicable to study the distribution patterns of various fluorescent or fluorescence-labelled substances in cells and tissues.
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