Abstract
Boron neutron capture therapy (BNCT) is a type of radiation therapy used in the treatment of cancerous tumors such as gliboblastoma multiforme and metastatic melanoma. BNCT is dependent on the site specific delivery and retention of boron‐10 atoms within the tumor. The ability of polyhedral borane anions to form covalent bonds with biochemical macromolecules appears to be critical for boron retention within the tumor cell. The polyhedral borane anions [B20H17OH]4−, [B20H18]2−, and [B20H17SH]4− were allowed to react with serum albumins, and the reaction products were investigated using polyacrylamide gel electrophoresis (Native‐PAGE), matrix assisted laser desorption ionization time of fight (MALDI‐TOF), electrospray ionization and nuclear magnetic resonance (NMR). The formation of disulfide linkage between [B20H17SH]4− and the free cysteine residue in the albumin was observed while [B20H17OH]4− and [B20H18]2− showed no evidence of covalent bonding. The understanding of covalent binding of polyhedral borane anions will aid in the synthesis and design of agents used in BNCT.
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