Abstract
Familial Mediterranean fever (FMF) is one of the most common autoinflammatory disorders and is characterized by episodic attacks of fever, along with inflammation. FMF pathogenesis is associated with various mutations in the MEFV gene, which encodes pyrin. Pyrin is expressed predominantly in neutrophils that have an important role in the innate immune response. Several proteins related with actin machinery have been identified as pyrin-interacting proteins in our in vitro cell migration models. Thus, in this study, we hypothesized that pyrin may have a key role in neutrophil migration during inflammation and decided to do functional analysis on pyrin silenced cell lines and primary neutrophils.
Highlights
Familial Mediterranean fever (FMF) is one of the most common autoinflammatory disorders and is characterized by episodic attacks of fever, along with inflammation
FMF pathogenesis is associated with various mutations in the MEFV gene, which encodes pyrin
Pyrin is expressed predominantly in neutrophils that have an important role in the innate immune response
Summary
Familial Mediterranean fever (FMF) is one of the most common autoinflammatory disorders and is characterized by episodic attacks of fever, along with inflammation. FMF pathogenesis is associated with various mutations in the MEFV gene, which encodes pyrin. Pyrin is expressed predominantly in neutrophils that have an important role in the innate immune response. Several proteins related with actin machinery have been identified as pyrin-interacting proteins in our in vitro cell migration models. In this study, we hypothesized that pyrin may have a key role in neutrophil migration during inflammation and decided to do functional analysis on pyrin silenced cell lines and primary neutrophils
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