Abstract
The acid–base equilibrium of mycophenolate mofetil is studied in the absence and presence of β-cyclodextrin (β-CD). The conditional acidity constants are obtained by rank annihilation factor analysis (RAFA) as a function of β-CD concentrations. Also the stability constants for inclusion complexes of β-CD with both acidic and basic forms are calculated. The conditional acidity constant decreases by increasing β-CD concentration. The calculated stability constants show that the acidic form of mycophenolate mofetil forms more stable inclusion complex (552±7M−1) than its basic anionic form (158±2M−1).
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Schedule a callMore From: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
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