Investigation of the impact of Prostrolane Natural-B on the main pathogenetic links of inflammatory skin aging

Abstract

Objective — to investigate the effectiveness of Prostrolane Natural-B (injectable biorevitalizant with filling effect) in patients with age-related skin changes based on the dynamics of immunohistochemical markers of inflammatory aging of the skin.Materials and methods. 20 female patients (mean age 45.2 years) with manifestations of age-related skin changes (laxity, wrinkles, dyschromia, increased vascular pattern) of the face, neck and decollete areas were treated with an investigational drug: two procedures of skin biorevitalization with 2 weeks interval. In order to identify microscopic and immunohisto-chemical differences, a comprehensive pathological study was carried out of 40 punch biopsies (diameter — 4 mm) taken in 20 patients from the studied skin areas on «day 1» — 1 week before the start of therapy, and on «day 35» — 2 weeks after the last procedure. The evaluation of the effectiveness of therapy based on the data obtained was conducted. According to the research results comparative graphs and tables were created.Results and discussion. After completing the course of biorevitalization with Prostrolane Natural-B: 1) the severity of perivascular and perifollycular inflammatory infiltration was statistically significantly reduced (p < 0.05); 2) the severity of follicular spongiosis decreased statistically significantly (p < 0.05); 3) there was a decrease in the specific density of CD68+-cells in the dermis (t = 2.55, p = 0.02); 4) a statistically significant decrease in the CD4+/CD8+ ratio was observed (t = 2.96, p = 0.005).Conclusions. Prostrolane Natural-B has an anti-inflammatory effect, reduces «smoldering» chronic inflammation, which can slow down the aging process of the skin and reduce their manifestations in the form of dyschromia and excessive expression of the vascular component by reducing the pro-inflammatory activation of skin cells, endothelial cells and melanocytes.