Abstract
The damaging effects of solar ultraviolet (UV) radiation exposure to human skin are well known and can reach from accelerated skin aging (photoaging) to skin cancer. Much of the damaging effects of solar UVA (320–400 nm) radiation is associated with the induction of reactive oxygen species (ROS), which are capable to cause oxidative damage to DNA like the oxidized guanosine 8-hydroxy-2' -deoxyguanosine (8-OHdG). Therefore, new UV protective strategies, have to be tested for their efficiency to shield against UV induced damage. We investigated the protective effects of HelioVital sun protection filter foil against UVA1 irradiation in skin cells. It could be shown, that HelioVital sun protection filter foil has protective effects against UVA1 irradiation induced changes in matrix metalloproteinase (MMP) expression. Furthermore a UVA1-dependant regulation of MMP15 in human fibroblasts could be shown for the first time in this context. In addition, this study demonstrated the protective effect of the HelioVital filter film against UVA1-induced ROS production and DNA damage. These results could pave the way for clinical studies with HelioVital filter foil shielding against the damaging effects of phototherapy and other forms of irradiation therapy, thereby increasing the safety and treatment opportunities of these forms of therapy.Graphical abstract
Highlights
Most of the solar UV radiation reaching the surface of the earth consists of UVA (320–400 nm, subdivided in UVA2 (320–340 nm) and UVA1 (340–400 nm) [1]) radiation and only approximately 5% of UVB (280–320 nm) radiation [2]
The results showed that UVA1 irradiation-induced DNA damage, matrix metalloproteinases (MMP) expression and reactive oxygen species (ROS) production can be ameliorated by HelioVital filter foil
The application of HelioVital filter foil ameliorated this UVA1-induced effect on proliferation (Fig. 2b, c), which might be due to less UVA1-induced DNA damage occurring in HelioVital filter foil protected skin cells
Summary
Most of the solar UV radiation reaching the surface of the earth consists of UVA (320–400 nm, subdivided in UVA2 (320–340 nm) and UVA1 (340–400 nm) [1]) radiation (approximately 95%) and only approximately 5% of UVB (280–320 nm) radiation [2]. UVAinduced ROS can cause oxidative damage to DNA like 8-hydroxy-2' -deoxyguanosine (8-OHdG) [4], DNA double-strand breaks [5], and mediate lipid and protein oxidation [6,7,8]. UVA can penetrate much deeper into the skin compared to UVB, increasing the amount of affected tissue [9]. The plethora of cellular damage caused by UVA can translate to macroscopic skin malformations such as accelerated skin aging (photoaging) [10] and skin cancer, like squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and melanoma [11], with continuously increasing prevalence and high mortality [12, 13]
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