Abstract
Background and objective: Vasculitis is a rare disease and its prevalence varies according to age, race, time and geographical location. Due to the fact that no study has been conducted in Iran to investigate the frequency, clinical and laboratory symptoms of vasculitis in a considerable population of vasculitis patients, so the need for this study is felt. The aim of this study was to evaluate the frequency and clinical signs of granulomatosis with polyangitis (GP) patients who admited in rheumatology ward of Valiasr hospital in the last 10 years.Methods and material: In this study, all patients with a possible diagnosis of vasculitis in the rheumatology ward of Valiasr Hospital during the past 10 years were evaluated. Then the GP patients were evaluated for clinical, laboratory, radiological, pathological findins, outcome, mortality, and major complications. Results: During the last 10 years, 223 vasculitis patients have been admitted to Valiasr hospital. Of these, 87 % were primary vasculitis and 13% were secondary vasculitis. The highest frequncy was related to GP (21.52 %) followed by Behcet's disease. Women and men were included 52.08 % and 47.91 % of GP patients, respectively. Upper and lower airway involvement and totally ear, nose and throat (ENT) involvement were the most common clinical symptoms in GP patients.Conclusion: According to the finding of this study, GP vasculitis was the most common type of vasculitis that ENT involvements were the most common clinical symptoms in this patients. However, more studies are required to confirm these data in Iran.
Highlights
Vasculitis means inflammation and swelling of the blood vessels, which can cause inflammation of the walls of the small vessels resulting in reduced blood flow and blockage of the vessels and lack of blood supply to various tissues and organs of the body
Diagnosis was initially performed according to the American College of Rheumatology (ACR) in 1990 by the Chapel Hill Consensus Conference (CHCC) criteria [7]
First, all vasculitis patients admitted to Valiasr Hospital over the last 10 years were selected
Summary
Vasculitis means inflammation and swelling of the blood vessels, which can cause inflammation of the walls of the small vessels resulting in reduced blood flow and blockage of the vessels and lack of blood supply to various tissues and organs of the body. 10 to 15 out of every one million people get the disease, most of whom are over 50 years of age [1]. Children and young people are at risk. The disease can be diagnosed by angiography or biopsy (taking a small piece of tissue from the affected area of the body). The symptoms are swelling of blood vessels in the affected part of the body and even rupture and internal bleeding in the same part [2]. There are two types of vasculitis; namely, primary and secondary, which have no underlying cause for the emergence of primary vasculitis, and the cause of secondary vasculitis is rheumatic diseases such as systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA) which are more prevalent [3]
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