Investigation of the effects of excipients on technological properties tablets of pyrola rotundifolia extract

Abstract

Aim of the work. To study the influence of excipients on the pharmacological and technological properties of round-leaved wintergreen extract tablets.Methods. The subject of the study were 27 series of round-leaved wintergreen extract tablets. The study of the influence of excipients on the pharmacological and technological properties of tablets, namely: abrasion, strength, disintegration, homogeneity were carried out in accordance with the requirements of SPhU 2 edition. The appearance of tablets of round-leaved wintergreen extract was estimated on a five-point scale.Results. The effect of 27 excipients on the pharmaco-technological indicators of the quality of tablets was studied during the creation of tablets by the method of direct compression. The experiments were done using the mathematical planning of the experiment – the Graeco-Latin square of the 2nd order.The results of the dispersion analysis of experimental data showed that the highest estimation of the appearance obtained tablets with neusilin US 2, vivapur 102, vivapur 112, pearlitol 100SD-mannitol.The best value for homogeneity of dosage of tablets with round-leaved wintergreen extract was obtained using potato starch, calcium anhydrous hydrogen phosphate, vivapur 302, pearlitol 300 DC-mannitol.The fastest breakdown tablets were round-leaved wintergreen extract with neusilin US 2, magnesium stearate, sodium croscarmellose, flovelaks, vivapur 200, MCC burst, vivapur 302.The greatest value of the strength of tablets with round-leaved wintergreen extract was obtained with sodium croscarmellose, tabletose 80, and procolv SMCC 90.Lowest erosion of tablets with round-leaved wintergreen extract provide neusilin US 2, calcium stearate, sodium croscarmellose, procolv EASYtab SP, tabletose 80.The generalized function of desirability allowed to select the optimal levels of factors (excipients) for each group of factors: neusilin US 2, magnesium stearate, sodium croscarmellose, procolv EASYtab SP, flovelaks.Conclusions. With the help of the Graeco-Latin square of the 2nd order, the influence of the 27th excipients on the pharmaco-technological properties of the tablets (appearance, homogeneity of dosage, disintegration , strength and erosion) and the generalized index – the function of desirability were studied. The experimental results allowed to select optimal excipients for further technological research