Abstract
This study aimed to examine the biological activities of unique steroid hormone derivatives-steroidal imidazoheterocycles. The activity synthesized steroidal compounds were tested for the viability of JEG-3 trophoblast cells of choriocarcinoma. The results of the MTT cytotoxicity test showed that most of the examined steroidal imidazoheterocycles act proliferatively on the JEG-3 cell line, except (E, F, and J). Antiproliferative activity of these derivates is probably influenced by different substituents at position 17-C atom in the chemical structure of the hormone and by different substituents on the oxygen atom of acetamide group in the hormone molecule. In order to better confirm the antiproliferative activity of these derivatives, it is necessary to performed complex research on a large panel of cancer cell lines and by different assay.
Highlights
The placenta is one of the main tissues that synthesize steroid hormones and affect the normal maintenance of pregnancy and fetal development (KARAHODA et al, 2021)
The results of the MTT cytotoxicity test showed that most of the examined steroidal imidazoheterocycles act proliferatively on the JEG-3 cell line, except (E, F, and J). Antiproliferative activity of these derivates is probably influenced by different substituents at position 17-C atom in the chemical structure of the hormone and by different substituents on the oxygen atom of acetamide group in the hormone molecule
In order to better confirm the antiproliferative activity of these derivatives, it is necessary to performed complex research on a large panel of cancer cell lines and by different assay
Summary
The placenta is one of the main tissues that synthesize steroid hormones and affect the normal maintenance of pregnancy and fetal development (KARAHODA et al, 2021). Investigations of the mechanisms of synthesis, metabolism and secretion of steroid hormones are very important because disturbance of steroid hormones during pregnancy can lead to various disorders. The most common disorders are gestational diabetes, preeclampsia, Intrauterine Growth Restriction, and Gestational trophoblastic diseases (GTD) (SOLANO and ARCK, 2020). Gestational trophoblastic diseases occur due to abnormal, proliferating transformation of placental cells (trophoblasts). Gestational trophoblastic neoplasia (GTN) is a malignant formation of GTD and includes invasive moles, epithelioid trophoblastic tumor (ETT), placental site trophoblastic tumor (PSTT) and choriocarcinoma (LURAIN, 2010). Choriocarcinoma is a rare, highly malignant germ cell carcinoma (BENTLEY, 2003). There are two types of choriocarcinoma, namely gestational (GC) and non-gestational (NGC) which differentiate in the genetic profile, morphology, pathophysiology and prognosis (MELLO et al, 2017)
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