Abstract
BACKGROUND. Successful nebulization is a result of joint usage of nebulizer and medication, which equally define availability and disposition of the active substance. Amount of the substance delivered by different nebulizer systems may differ in more than 10 times.
 OBJECTIVE. The aim of the study was to investigate the distribution of aerosol particles of drugs for inhalation manufactured by «Yuria-Pharm» under conditions of usage of Ulaizer Home.
 MATERIALS AND METHODS. We investigated Ulaizer Home nebulizer and medications for inhalation (Decasan, Lorde hyal, Nebufluson, Nebutamol) with the help of new generation impactor (“Copley Scientific Limited”, Great Britain).
 RESULTS AND DISCUSSION. Mass median aerodynamic diameter (MMAD) of Decasan particles was 4.878 µm, geometric standard deviation (GSD) – 1.72. MMAD of Lorde hyal particles was 3.194 µm, GSD – 1.556. Drop distribution for Nebutamol was alike the distribution for non-viscous aqueous solutions (MMAD – 5.363 µm, GSD – 1.924). For Nebufluson MMAD was 5.491 µm, GSD – 1.724.
 CONCLUSIONS. The delivery of the inhaled drug to the required area of the respiratory system is a key to successful nebulization. It directly depends on the parameters of the aerosol. The distribution of particles of drugs manufactured by «Yuria-Pharm» in case of nebulization using Ulaizer Home allows to deliver the required amount of drug to the predefined parts of the respiratory system.
Highlights
Successful nebulization is a result of joint usage of nebulizer and medication, which define availability and disposition of the active substance
Amount of the substance delivered by different nebulizer systems may differ in more than 10 times
We investigated Ulaizer Home nebulizer and medications for inhalation (Decasan, Lorde hyal, Nebufluson, Nebutamol) with the help of new generation impactor (“Copley Scientific Limited”, Great Britain)
Summary
Дослідити розподіл частинок аерозолю інгаляційних препаратів виробництва «Юрія-Фарм» при використанні небулайзера Ulaizer home. За допомогою імпактора нового покоління (Copley Scientific Limited, Велика Британія) досліджено небулайзер Ulaizer Home та інгаляційні препарати (Декасан, Лорде гіаль, Небуфлюзон, Небутамол). Медіанний аеродинамічний діаметр за масою (МАДМ) частинок препарату Декасан становив 4,878 мкм, середнє геометричне відхилення (СГВ) – 1,72. МАДМ частинок препарату Лорде гіаль дорівнював 3,194 мкм, СГВ – 1,556. Розподіл крапель аерозолю для препарату Небутамол виявився подібним до такого препаратів нев’язких водних розчинів (МАДМ – 5,363 мкм, СГВ – 1,924). Для Небуфлюзону МАДМ дорівнював 5,491 мкм, СГВ – 1,724. Розподіл частинок препаратів виробництва «Юрія- Фарм» при небулізації за допомогою пристрою Ulaizer Home дозволяє доставити потрібну кількість лікарської речовини в необхідні відділи дихальної системи. National Medical University named after O.O. Bohomolets, Kyiv 2.
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