Abstract
Investigation of some toxic compounds concentrations in aerosol of new class of tobacco products - tobacco heating systems and comparing their levels with regular cigarettes aerosol is an important step in understanding whether these products are low-risk, as some manufacturers claim. Three popular in Russia cigarette brands, reference cigarette 3R4F and new heated tobacco products (HTP) were tested for levels of emissions of some harmful and potentially harmful constituents (HPHC). Aerosols of these products were collected under the ISO intense smoking regime and quantified for levels of N'-nitrosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, acrolein, acetaldehyde, formaldehyde. Levels of above mentioned HPHCs were measured by the high-performance liquid chromatography / mass spectrometry (HPLC/MS-MS). The results demonstrate that highest levels of measured HPHCs are obtained for reference cigarette 3R4F. As for popular in Russia cigarette brands their levels vary greatly and for some compounds can be very close to levels of 3R4F aerosol. Levels of all measured HPHCs in aerosol of HTP were significantly lower compared to all cigarettes. This can be explained by specific mechanism of HTPs aerosol formation without pyrolytic and pyrosynthetic reactions which are typical to all combustive tobacco products due to their high temperature of the process.
Highlights
Cigarette smoking is an established cause of serious health diseases including cardiovascular diseases, chronic obstructive pulmonary diseases (COPD), and cancer
Increasing alternatives to tobacco products have been introduced by various industry players in the global market. These products include Electronic Nicotine Delivery Systems (ENDS, called e-cigarettes) that heats a nicotinecontaining solution [3] and electronically Heat-notBurn (HNB) products referred as Heated Tobacco Products (НТРs) which heats a tobacco mixture without combustion or burning process [4]
Test products samples: tobacco heating system iQОS from Philip Morris Products S.A.; tobacco heating system Glo from British American Tobacco; The University of Kentucky 3R4F cigarettes, designed and manufactured in accordance with ISO 16055:2012 (Tobacco and Tobacco Products, Monitor Test Sample, Requirements and Use) were used as a reference samples for research, method validation, comparative tests, monitoring the correctness of the tests during routine analyses; three commercially available cigarettes from the Russian market were used for comparison
Summary
Cigarette smoking is an established cause of serious health diseases including cardiovascular diseases, chronic obstructive pulmonary diseases (COPD), and cancer. The actual worldwide policy of tobacco harm reduction recommends the necessity to put in place less harmful products available to smokers who would otherwise continue smoking. This strategy is promoted by various stakeholders, including regulators, public health organizations, healthcare professionals, and tobacco industry [2]. Increasing alternatives to tobacco products have been introduced by various industry players in the global market. These products include Electronic Nicotine Delivery Systems (ENDS, called e-cigarettes) that heats a nicotinecontaining solution [3] and electronically Heat-notBurn (HNB) products referred as Heated Tobacco Products (НТРs) which heats a tobacco mixture without combustion or burning process [4]
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