Abstract
The current study explores the application of Ti3C2 MXene quantum dots (MQDs) as a chemiluminescent (CL) probe to determine uric acid (UA) in biological samples. The MQDs sensor was synthesized using ultrasonic-assisted hydrothermal method and characterized through Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy, energy dispersive X-ray analysis, high-resolution transmission electron microscopy, and X-ray diffraction. The presence of MQDs significantly enhances the ultra-weak Fe(II)–S2O82− CL system. Subsequently, quenching of the probe’s CL signal was observed in the presence of UA. Thus, the designed CL sensor offers an excellent analytical capability for determining UA in the 0.15–2.5 µM range, with a limit of detection of 0.093 µM. The method was effectively used to analyze UA in human serum and urine, yielding recovery rates between 94.4 % and 108.3 % with relative standard deviations (RSD) ranging from 1.9 % to 5.9 %.
Published Version
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