Investigation of the association between oxygen reserve index and arterial partial oxygen pressure in anesthetized dogs

Abstract

ObjectiveTo evaluate the relationship between oxygen reserve index (ORI) and arterial partial pressure of oxygen (PaO2) in anesthetized dogs. Study designProspective experimental study. AnimalsA total of eight healthy adult Beagle dogs with a median age of 38 (range 20–87) months and a median body mass of 8.6 (range 7.0–13.8) kg. MethodsAfter induction of general anesthesia with propofol, dogs were mechanically ventilated and anesthesia maintained with isoflurane carried in oxygen. Arterial blood samples were collected from a catheter placed in the femoral artery. ORI was measured by placing a CO-oximeter sensor on the tongue. Inspired oxygen fraction (FiO2) was increased from 21% to > 95% in increments of 5%. PaO2 and ORI were recorded and compared at different times. The relationship between ORI and PaO2 was investigated using a nonlinear function, the Hill equation, and a linear regression analysis was performed, as appropriate. ResultsA total of 128 pairs of values were compared for all dogs. Applying the Hill equation to the relationship between ORI and PaO2 resulted in R2 = 0.80 (p < 0.001) with a Hill coefficient of 3.7. It was predicted that ORI ranged 0.1–0.9 as PaO2 ranged 127.0–417.9 mmHg and that in the more linear portion of the range, PaO2 of 127.0–289.9 mmHg ORI ranged 0.1–0.7. Linear regression analysis in the more linear portion showed a weak correlation (R2 = 0.29, p = 0.006). Conclusions and clinical relevanceIn the present study, the Hill equation predicted the relationship between PaO2 and ORI for PaO2 ranging 127.0–417.9 mmHg in anesthetized dogs. However, in the linear portion of the PaO2, the coefficient of determination was low, indicating that ORI is not a surrogate for PaO2.