Abstract
Coordination-driven self-assembly is an effective synthetic tool for the construction of spatially and electronically tunable supramolecular coordination complexes (SCCs), which are useful in various applications. Herein, we report the synthesis of a two-dimensional discrete metalla-rectangle [(η6-p-cymene)4Ru4(C6H2O4)2(2)2](CF3SO3)4 (3) by the reaction of a dinuclear half-sandwich ruthenium (II) complex [Ru2(η6-p-cymene)2(C6H2O4)Cl2] (1) and bis-pyridyl amide linker (2) in the presence of AgO3SCF3. This cationic ruthenium metalla-rectangle (3) has been isolated as its triflate salt and characterized by analytical techniques including elemental analysis, Fourier-transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance spectroscopy (1H-NMR), carbon nuclear magnetic resonance spectroscopy (13C-NMR), 1H-1H correlation spectroscopy (COSY), 1H-1H nuclear Overhauser effect spectroscopy (NOESY), diffusion ordered spectroscopy (DOSY), and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). Significantly, the 2D cationic ruthenium metalla-rectangle showed better anticancer activity towards three different cell lines (A549, Caki-1 and Lovo) as compared with the parent ruthenium complex (1) and the commercially used drug, cisplatin.
Highlights
Self-assembly is a vital synthetic tool for the construction of discrete two-dimensional and three-dimensional architectures
S2) is discrete architectures based on the symmetry of organic linkers
4-aminopyridine discrete architectures based on the symmetry of organic linkers
Summary
Self-assembly is a vital synthetic tool for the construction of discrete two-dimensional and three-dimensional architectures. The dynamic imine chemistry is widely utilized for the preparation of platonic, multi-carboxylate anions is of significant importance owing to their crucial role in chemical, biological, Archimedean, stellated, and faceted solids [44]. The significance and usefulness of the coordination-driven approach, Thisherein, may raise the chance ofarene-Ru a potential substitute to been cisplatin, whichand hasscreened various drawbacks such as a self-assembled derivative has prepared for its antitumor. This may raise chance of a potential substituteand to cisplatin, which has various drawbacks the activity.
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